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From the perspective of a posren who spends about 1/2 of my time in hotels, I have to say Hilton Honors. I'm a member of all the major ones, but Hilton (which includes hampton inn, embassy suites, homewood suites, doubletree, and hilton) offers the most opportunity to earn points and are the easiest to deal with when it comes to using your points. I've traveled to the carribean, many destinations in the southeast and taken quite a few weekend jaunts with my points, and never any hassle.References :